Israel: Cannabis Can Help Heal Bone Fractures, According To Study
Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts
According to the research, the administration of the non-psychotropic component significantly helps heal bone fractures
By Michael Bachara
Cannabis was used as a medical remedy by societies around the world for centuries. Therapeutic use of cannabis was banned in most countries in the 1930s and '40s due to reefer madness campaigns without merit. Significant medical benefits of cannabis in alleviating symptoms of such diseases as Parkinson's disease, cancer, multiple sclerosis and post-traumatic stress disorder are being discovered by researchers throughout the world.
In a 2015 study published in the Journal of Bone and Mineral Research by Tel Aviv University and Hebrew University researchers explored promising medical application for cannabis. According to the research, the administration of the non-psychotropic component cannabinoid cannabidiol (CBD) significantly helps heal bone fractures. The study, conducted on rats with mid-femoral fractures, found that CBD - even when isolated from tetrahydrocannabinol (THC), the major psychoactive component of cannabis - markedly enhanced the healing process of the femora after just eight weeks.
The research was led jointly by Dr. Yankel Gabet of the Bone Research Laboratory at the Department of Anatomy and Anthropology at TAU's Sackler Faculty of Medicine and Professor Itai Bab of Hebrew University's Bone Laboratory, who directed the project until his passing.
The same team, in earlier research, discovered that cannabinoid receptors within our bodies stimulated bone formation and inhibited bone loss. This paves the way for the future use of cannabinoid drugs to combat osteoporosis and other bone-related diseases.
"The clinical potential of cannabinoid-related compounds is simply undeniable at this point," said Dr. Gabet. "While there is still a lot of work to be done to develop appropriate therapies, it is clear that it is possible to detach a clinical therapy objective from the psychoactivity of cannabis. CBD, the principal agent in our study, is primarily anti-inflammatory and has no psychoactivity."
According to Dr. Gabet, our bodies are equipped with a cannabinoid system, which regulates both vital and non-vital systems. "We only respond to cannabis because we are built with intrinsic compounds and receptors that can also be activated by compounds in the cannabis plant," he said. The researchers found that the skeleton itself is regulated by cannabinoids. Even the addition of a non-psychogenic compound acting outside of the brain can affect the skeleton.
The U.S. Government continues to ban the herb, classifying it as one of the “most dangerous” drugs with “no currently accepted medical use.”
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